Expedition 50 is the 50th expedition to the International Space Station.

Robert S Kimbrough, Andrei Borishenko and Sergey Ryzhikov, transferred from Expedition 49. Expedition 50 began upon the departure of Soyuz MS-01 on October 28, 2016 and will be concluded upon the departure of Soyuz MS-02 on March 2017. The crew of Soyuz MS-03 are then to transfer to Expedition 51.

After the launch of Soyuz MS-03, Peggy Whitson at age 56, became the oldest woman to fly into space. She will also become the first woman to command two ISS expeditions (will command Expedition 51 Soyuz MS-03 docked at the International Space Station on November 19, 2016, bringing the total number of people in the station to 6.